Fraunhofer Institute for Applied Optics and Precision Engineering IOF
Fraunhofer Institute for Applied Optics and Precision Engineering IOF

Biophotonic Sensors

Biophotonic systems and sensors enable the life and environmental sciences to carry out quick and precise analyses. They are used for various detection tests, including the observation of molecular bonding events on surfaces.

The applications of optical sensors for biochemical diagnostics range from human and veterinary medicine all the way to environmental and foodstuff analysis.

 

Are you looking for biophotonic systems or sensors?

Please contact us. We will then develop a customer-specific solution for your problem.

In the field of biophotonic sensors, Fraunhofer IOF is developing, among other things:
Disposable chips for parallel label-free analyses

Disposable sensors for multi-spot label-free analyses

Analytical system comprising SPR optical readout, sampler and syringe pump.
© Fraunhofer IOF
Analytical system comprising SPR optical readout, sampler and syringe pump.
Photograph of the gold coated polymer chip with flow cell (separated).
© Fraunhofer IOF
Photograph of the gold coated polymer chip with flow cell (separated).
Optical chip coated with BSW sensor stack for combined label-free and fluorescence sensing.
© Fraunhofer IOF
Optical chip coated with BSW sensor stack for combined label-free and fluorescence sensing.

Our offer:

Label-free, parallel optical biosensing based on low cost polymer substrates for various applications.

 

Examples for applications:

  • Aptamer based Thrombin sensing: A. Henseleit, et al., Eng. Life Sci. 11, 573
  • CMV detection in human serum: F. Sonntag et al., Proc. SPIE 7365, 73650Q
  • DNA hybridization arrays: A. Kick et al., Biosens. Bioelectron. 26, 1543 and N. Danz et al., Eng. Life Sci. 11, 566
  • Virus detection in plants: K. Florschütz et al., J. Virolog. Meth. 189, 80
  • Albumin monitoring in cell cultures: A. Henseleit et al., J. Sens. Sens. Syst. 4, 77

 

Technology / approach:

  • Patented approach utilizing the wellknown sensitive SPR method
  • Temporally resolved analysis for determination of kinetic parameters
  • Angularly resolved analysis comprising high linearity and measurement range
  • Up to 60 Spots detected simultaneously within one micro channel
  • Introduction of redundancy as well as positive and negative controls possible
  • Simple ‘click-in’ handling
  • Polymer chip and cover components ensure low costs for large batch volumes

 

Outlook:

Dielectric thin film stacks for enhanced labelfree performance and combined label-free and fluorescence analysis.

  • A. Sinibaldi et al., Sens. Act. B 174, 292
  • N. Danz et al., Proc. SPIE 9506, 95060V